For example, rare variants −91 C→A in 5′-UTR exon 1 and the Ala105Thr missense mutation of TFAM were shown to be involved in the pathogenesis of cardiac hypertrophy [306] and variants rs10826175 (A→G) SNP upstream and rs1937 (G→C) SNP in exon 1 of TFAM were associated with diffuse-type gastric cancer [274]. The gene discussed is TFAM; the disease is cardiac hypertrophy.