To explore the bioactive component in HLAB against obesity, the inhibitory activities of cellular exopolysaccharides (EPSs) isolated from kefir L. kefiri (LKDH1, 3, and 5) and L. mesenteroides (LMDH4, 6, 7, and 8) on lipid accumulation were determined in 3T3-L1 cells using an Oil red O staining. This evidence concerns the gene HLA-B and obesity due to melanocortin 4 receptor deficiency.