FNDC5 and ischemic stroke: Another recent study by Peng et al. (2017) showed that irisin mitigates oxygen-glucose deprivation-induced neuronal injury in part by inhibiting the ROS-NLRP-3 (reactive oxygen species-Nod like receptor pyrin-3) inflammatory signaling pathway, indicating a possible mechanism for irisin induced therapeutic effects in ischemic stroke [104].