Of note, a recent study which combines proteomic and genomic analysis on colon cancer [33] revealed deregulation of ORP3 in 6.6% of colon cancer patients (4.72% mutations and 1.89% amplifications), as determined by the cBio Cancer Genomics Portal [34,35], supporting the idea that ORP3 may contribute to colon cancer initiation and/or progression. This evidence concerns the gene OSBPL3 and colonic neoplasm.