In recent years, nectin cell adhesion molecule 4 (NECTIN4) has been identified as an important factor in several malignant tumors, including urothelial carcinoma, gastric cancer, thyroid cancer, breast cancer, esophageal cancer, and ovarian cancer [15,16,17,18,19,20,21]. The gene discussed is NECTIN4; the disease is thyroid gland carcinoma.