S100A6 and cancer: Figure 9J shows that although the 200 N-terminal residues of ANXA11 are intrinsically disordered, this region contains two MoRFs (residues 39-49 and 143-212), one of which includes the aforementioned ANXA11 region engaged in the S100A6 binding. In addition to its role in cell cycle regulation and cancer development, the S100A6-ANXA11 complex can be engaged in triggering a cascade for sex determination via some cell stage-specific events [172].