In both our study and that of Batlle’s group, genes encoding subunits of RNA polymerases were found; however, while we detected differences in the expression of three RNA polymerase II subunits (POLR2H, POLR2J, and POLR2M, with the first common to all three RNA polymerases) between rectal and colon tumor organoids, Batlle’s group referred to elevated levels of RNA polymerase I subunit A (POLR1A) as a critical feature of top CSC in CRC. Here, POLR2J is linked to colonic neoplasm.