The findings in some of these studies [33,43,45,46] have additionally suggested that ZKSCAN3 could modulate several molecules known to play a key role in tumorigenesis and/or tumor progression, such as cyclin D1/D2, EGF, IGF-2, integrin-β4, MMP2/MMP9, NF-κB, and VEGF. This evidence concerns the gene IGF2 and neoplasm.