By screening 10 genes involved in ACM and related cardiomyopathies (ACTN2, DSG2, DSC2, PKP2, DSP, LDB3, JUP, RYR2, TGFβ3, TMEM43), authors identified a likely-pathogenic ACTN2 variant (p.Y473C) [35]. Here, ACTN2 is linked to cardiomyopathy.