CST3 and hepatocellular carcinoma: The aim of this present study is to define a structural model of the stable human cystatin C oligomers by combining information from the crystal structure of monomeric stab-1 HCC [14], along with experimental measurements of the oligomers obtained using transmission electron microscopy (TEM), atomic force microscopy (AFM) and small-angle X-ray scattering (SAXS) techniques, with molecular dynamics (MD) simulations.