It is important to note that the exaggerated inflammatory response to COVID-19 infection makes it difficult to differentiate an IBD flare from COVID-19 GI manifestations, using well-studied inflammatory markers (such as C-reactive protein—CRP, erythrocyte sedimentation rate—ESR) and, as such, we feel it is important to make this determination using a GI-specific marker. This evidence concerns the gene CRP and inflammatory bowel disease.