Hitherto, interactions between ABC proteins and phytochemicals, especially flavonoids, have attracted a lot of interest within the frameworks of multi-drug resistance (MDR) in cancer chemotherapy and the intestinal absorption of a variety of drugs, bioactive food ingredients, and/or toxins upon oral uptake because most ABC proteins are known to significantly affect the pharmacokinetic features of their substrate xenobiotics. This evidence concerns the gene ABCB6 and cancer.