It regulates several signalling axes including Extracellular signal-regulated kinase (ERK), p38, mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), Phosphatidylinositol-3-kinase (PI3)-protein kinase B (PKB, also known as AKT), acting primarily as a tumour suppressor in premalignant epithelial cells but switching to an EMT promoter as cancer evolves [36]. This evidence concerns the gene AKT1 and neoplasm.