Thus, given the known crosstalk between TGF-β signalling and other pathways including Wnt [11], the association of β-catenin with increased proliferation and poor survival in BC patients [38] and the observation that shRNA-mediated knockdown of SnON has been shown to increase migration and invasion in breast and lung cancer cells [39]. This evidence concerns the gene TGFB1 and lung carcinoma.