CAFs secrete various growth factors such as TGF-β, HGF, FGF and chemokine CXCL12/SDF-1 (C-X-C motif chemokine ligand 12 or Stromal cell-derived factor 1), which together promote tumour growth, EMT and invasion in cancer cells [4]. This evidence concerns the gene TGFB1 and neoplasm.