Inhibition of constitutive and radiation-induced NF-κB activity by PN (Figure 2, Section 1) sensitized prostate cancer cells to X-ray, inhibited expression of superoxide dismutase 2 (SOD2) gene and split-dose repair and activated the PI3K-AKT pathway [176,177]. The gene discussed is NFKB1; the disease is Familial prostate cancer.