F11R and metabolic dysfunction-associated steatotic liver disease: In an integrated study involving animals and humans, the authors reported that mice with defects in intestinal permeability develop more severe steatohepatitis after a high fructose, cholesterol diet than control mice, and colon tissues from patients with NAFLD have lower levels of JAM-A (junctional adhesion molecule), and higher levels of inflammation than subjects without NAFLD [250].