Several cytokines and chemokines (e.g., GM-CSF, G-CSF, CCL2, CXCL1) induce the mobilization of MDSCs from bone marrow to the peripheral lymphoid organs and to the TME, where they promote tumor immune evasion through direct or indirect mechanisms, both antigen-specific and unspecific [61]. The gene discussed is CXCL1; the disease is neoplasm.