ALOX15B and hereditary clear cell renal cell carcinoma: In renal cell carcinoma (RCC), TAMs produce high levels of lipid-derived 15-hydroxyeicosatetraenoic acid through the enzymatic activity of 15-lipoxygenase 2 (15-LOX2), which positively correlates with CCL2 and IL-10 secretion, supporting pro-tumoral inflammation [159].