Additionally, small-molecule agonists of TLR7/TLR8 directly activate maturation of APCs and promote anti-tumor activity [102]; stimulator of interferon genes (STING) agonists induce pro-inflammatory cytokine production and type I IFN-related responses, which in turn activate DCs and TAMs, promoting T cells’ priming in lymph nodes and recruitment into TME [103]. This evidence concerns the gene STING1 and neoplasm.