While PIT infarction makes cell apoptosis and clear infarction margins with no penumbra, the reperfusion process followed by occlusion with MCAO could make a penumbra area, mimicking the human ischemic stroke pathophysiology more [13]; a recent study reported that exercise improved the expression of neuroplasticity proteins including tau and brain-derived neurotrophic factor (BDNF) in a MCAO model of rats [14]. This evidence concerns the gene BDNF and ischemic stroke.