The most commonly detected CH mutations are from genes DNMT3A, TET2 and ASXL1, which are epigenetic modulators [57,59,60,61,62], followed by JAK2, PPM1D, TP53, IDH2, SF3B1 and SRSF2 [5,50,52,53,57]. The gene discussed is TP53; the disease is cyclic hematopoiesis.