Before anti-TB treatment, the in vitro levels of granulysin, perforin, granzyme-B and IFN-γ released from PBMCs of active TB or HIV/TB coinfection patients after PPD and H37Ra stimulation were analyzed in comparison with those of HIV+HAART−, HIV+HAART+ and healthy individuals (HC) as controls (Table 1). The gene discussed is PRF1; the disease is tuberculosis.