Obviously, after completion of treatment, the median granzyme-B levels after PPD or H37Ra stimulation of PBMCs significantly decreased in TB (PPD: before treatment, 919.33 pg/mL; after treatment, 282.0 pg/mL, p = 0.003 and H37Ra: before treatment, 527 pg/mL; after treatment, 431 pg/mL, p = 0.028) (Figure 2e), tended to decrease after PPD stimulation in HIV/TB coinfection (before treatment, 982.67 pg/mL; after treatment, 161.0 pg/mL, p = 0.285), and increased after H37Ra stimulation (before treatment, 99.33 pg/mL; after treatment, 713.0 pg/mL, p = 0.593) (Figure 2f). The gene discussed is GZMB; the disease is tuberculosis.