In vivo, we assess tumor specificity of SDC1-Lip in orthotopic murine models of pancreatic cancer with multispectral optoacoustic tomography (MSOT), a high-precision imaging modality with enhanced 3D spatial resolution [35,36], and efficacy of SDC1-Lip delivery of echinomycin as a potential treatment for apoptosis-resistant pancreatic cancer in vivo. The gene discussed is SDC1; the disease is familial pancreatic carcinoma.