In turn, Tan et al. revealed that SOD-3 protects against proteinuric kidney disease in mice [53], and Fujita et al. indicated, on the basis on diabetic mouse models, that the downregulation of renal SOD-1 and SOD-3 may play a key role in the pathogenesis of diabetic nephropathy [54]. The gene discussed is SOD3; the disease is diabetic kidney disease.