ANXA8 and pancreatic neoplasm: A pancreatic cancer study speculated that ANXA8 expression was low in a normal pancreas due to CpG hypermethylation of the ANXA8 promoter-exon 1 region, while demethylation of the ANXA8 promoter-exon 1 region induced ANXA8 upregulation in pancreatic cancer that invaded the surrounding tissue and metastasized [149].