If this is not possible, a COI value of < 0.2 in the ECLIA or a S/C value < 0.22 in the IgG and IgA ELISAs regardless of the hematocrit result would, with a high probability, correspond to a negative result in serum, even in patients with anemia (not lower than a hematocrit of 20%, which corresponds to a hemoglobin level of 67 g/L using the rule of three for converting hematocrit into hemoglobin levels [24]). The gene discussed is CD79A; the disease is anemia (phenotype).