Typically, infiltrated Foxp3+ Tregs in TME exert suppression on effector function by secreting inhibitory cytokines, IL-10 and TGF-β or through the cell-mediated engagement of inhibitory receptors (IRs), T cell immunoreceptor with Ig and ITIM domains (TIGIT), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein-1 (PD-1), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) [32,33,34] and promotes the exhaustion-associated transcriptomic machinery in tumor infiltrated lymphocytes. This evidence concerns the gene HAVCR2 and neoplasm.