Also, Ene-Obong et al. reported that aPSCs sequester antitumor CD8+ T cells around nonadjacent regions in the stroma, resulting in low infiltration of CD8+ cells into the primary tumor epithelial cells in KPC (Pdx-1-Cre; LSL-KrasG12D/+; LSL-Trp53R172H/+) mice, which is associated with shorter survival in human PDAC [69]. The gene discussed is CD8A; the disease is neoplasm.