Investigation of CAR-TILs by Chen et al. corroborated the findings of Liu et al. As such, Nr4A1 and NR4A2 expressions were positively correlated with the expression of PD-1 and TIM-3, and NR4A was enriched in transcriptionally active and accessible regions in CD8+PD-1high TILs from human melanoma and non-small cell lung cancer [148,164]. This evidence concerns the gene PDCD1 and melanoma.