CD4 and neoplasm: Programmed cell death-1 (PD-1), mostly expressed on effector CD4+ Th cells and CD8+ TILs [90,97,98,99], binds to its ligands, PD-L1 and PD-L2, on solid tumors [100], on tumor-infiltrating dendritic cells [101], and on tumor associated-macrophages and MDSCs [102], to prevent chronic activation of T cells [15] (Figure 2).