CCND1 and breast carcinoma: Thymoquinone induces apoptosis in T-47D and MDA-MB-468 breast cancer cells by promoting G(1) phase arrest via translation upregulation of procaspase-3, Bax and cytoplasmic cytochrome 3, inhibition of cyclin D1 and cyclin E, and PARP cleavage alongside downregulation of the gene expression of survivin, Bcl-2 and Bcl-xL [44] (Table 1).