In another study using the MCF-7 human breast cancer cells, curcumin reversed the proliferative effects of bisphenol A (BPA) by downregulating oncogenic miR-19b and miR-19a and their downstream targets such as p53, p-Akt, PTEN and p-MDM2, and multiplying cell nuclear antigen [135]. This evidence concerns the gene TP53 and breast cancer.