NFKB1 and breast carcinoma: Furthermore, the mechanism by which Rh2 exerts its anti-cancer activity involves inhibiting the manufacture of inflammatory cytokines such interleukin (IL)-1β and tumor necrosis factor (TNF)-α through obstructing the nuclear factor (NF)-κB signaling and mitogen-activated protein kinase pathways in MCF-7 breast cancer cells [34,35].