GBM-derived exosomes serve a core role in angiogenesis due to their cargo, which includes pro-angiogenic factors (e.g., VEGF, transforming growth factor beta type 1 [TGF-β1], C-X-C chemokine receptor type 4 [CXCR4] and plasminogen activators), miRs and extracellular proteolytic enzymes [35]. The gene discussed is CXCR4; the disease is glioblastoma.