Exploiting this hypothesis, Mallawaaratchy et al. [66] described several proteins discharged from GBM-derived exosomes that are associated with invadopodia biogenesis and subsequent GBM invasive potential, such as Annexin A1 (ANXA1), integrin β1 (ITGB1), actin-related protein 3 (ACTR3), programmed cell death 6-interacting protein (PDCD6IP) and calreticulin (CALR), among others. This evidence concerns the gene PDCD6IP and glioblastoma.