The median MMP-1 concentration in saliva from stages I, II, III, and IV OSCC patients was 382.5, 1324.4, 2912.6, and 2775.4 pg/mL, respectively, and the median fold-difference between the corresponding stage and OPMD II (median, 57.7 pg/mL) was 6.6-, 23.0-, 50.5-, and 48.1-fold, respectively. Here, MMP1 is linked to oculopharyngeal muscular dystrophy.