MMP1 and esophageal squamous cell carcinoma: In recent years, it has been shown that MMP-1 protein is an unfavorable prognostic marker for a number of cancers, including salivary gland cancer [69], nasopharyngeal carcinoma [70], gastric cancer [71], thyroid follicular carcinomas [72], esophageal squamous cell carcinoma [73], and OSCC [74].