NFKB1 and sarcoidosis: Various SNPs located near the nuclear factor kappa B subunit 1 (NFKB1) and MANBA (beta-D-mannoside mannohydrolase) genes on chromosome 4q24 showed a significant association with sarcoidosis, but no functional relationship has been established despite the well-known role of NF-kappa-B, a pleiotropic transcription factor in a vast array of stimuli related to inflammation, immunity, differentiation, cell growth, and apoptosis [18,21].