Interestingly, annexin A11 has a long hydrophobic N terminal sequence binding members of the S100 proteins family, such as S100A6 (calcyclin), and whose mutations have been linked to amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by defective autophagy and intracellular vesicular traffic in neuronal tissues [61,62]. The gene discussed is S100A6; the disease is amyotrophic lateral sclerosis.