A recent report in a single case of familial sarcoidosis carrying the NOD2 G908R mutation, well-described in Crohn disease, was informative in that two pathogenic mutations in Rac1 regulators, KALRN (Kalirin) and EPHA2 (ephrin receptor A2), respectively, discriminate patients with sarcoidosis from intrafamilial NOD2 G908R + without the disease [87]. This evidence concerns the gene NOD2 and sarcoidosis.