Among 2446 genes significantly differentially expressed in monocytes between sarcoidosis and controls, the authors identified a downregulation of genes involved in proteasome degradation and ribosomal pathways, and conversely, an upregulation of genes, such as, for example, ATP6AP1 (ATPase H + transporting accessory protein 1), CYBB (cytochrome b-245 beta chain), LAMP2 (lysosomal-associated membrane protein), PLK1 (serine/threonine-protein kinase or polo-kinase 1), and SERPINA1 (serpin family A member 1, encoding alpha-1 antitrypsin), implicated in phagocytosis and lysosomal pathways. The gene discussed is CYBB; the disease is sarcoidosis.