IL10 and colorectal carcinoma: Intriguingly, a recent murine study by Tomkovich, et al. [6], intended to delineate the causality of microbial biofilms in CRC, successfully demonstrated that the polymicrobial biofilms are carcinogenic in a preclinical in vivo experiment with the use of three genetic murine models of CRC carcinogenesis (germ-free ApcMinΔ850/+; Il10−/− or ApcMinΔ850/+ and specific pathogen-free ApcMinΔ716/+ mice).