Additionally, AGN extract prevented epithelial injury in colonic tissues of a murine model of dextran sulfate sodium-induced ulcerative colitis by moderating the activation of inflammatory mediators, such as IL-6, TNF-α, prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2) [33]. Here, IL6 is linked to ulcerative colitis.