Increased levels of LPS activate TLR4 and have been observed in the serum of steatotic patients and in diet-induced NAFLD/NASH models (HFD, fructose-rich diet, methionine/choline-deficient diet, and choline-deficient L-amino acid-defined diet), where lack of TLR4 showed reduced liver damage, in terms of steatosis or steatohepatitis [279,282]. The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatohepatitis.