Although insulin resistance (IR) is known as a powerful predictor of T2DM development and a therapeutic target once hyperglycemia is present, distribution curves of insulin sensitivity as measured by the euglycemic-hyperinsulinemic clamp show that people with T2DM sit within the range of the non-diabetic distribution, but toward the lower range [16], which needs a health specialist for such examination. This evidence concerns the gene INS and type 2 diabetes mellitus.