Thus, we found that lowered blood concentrations of cytokines/chemokines such as Flt3 ligand, GM-CSF, and MCP-1 are significantly associated with the relative risk of early IHD in young people aged 25–44 years.In addition, in young people 25–44 years old with AO, lowered blood concentrations of cytokines/chemokines are significantly associated with the relative risk of early IHD comorbid with AO: GM-CSF, MCP-1, and IL-4. Here, CSF2 is linked to myocardial ischemia.