Resveratrol, as a polyphenol with powerful antioxidant properties inhibiting lipid accumulation, improving insulin sensitivity, and reducing triglyceride levels in serum, appears to be an effective, natural, and safe complementary treatment option in NAFLD therapy, particularly arising as a result of obesity and/or insulin resistance [2,36,37,38]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.