EPHA2 and myocardial infarction: Our previous work revealing the cardioprotective benefits of endogenous ephrinA1-Fc administration in both acute I/R [16,18] and chronically nonperfused MI [17], as well as the severity of ischemic injury in both control and hyperglycemic EphA2-R-M mice [19,43], validate the critical importance of this bidirectional signaling system in mitigating several aspects of early injury.