CD8A and neoplasm: It is worth noting that the ability to reduce the number of MDSCs and increase the CD8/MDSC ratio induced by the vaccine was attenuated in mice immunized eight times, compared with those immunized five times, suggesting that compared with the immunosuppressive MDSCs, CD8+ T cells that inhibited tumor growth were expressed at higher levels, and regulated the immune microenvironment to actively suppress tumor states, suggesting an increase in antitumor activity in mice immunized five times.