We found that CD83-KD ovarian cancer cells exhibited elevated transcriptional expression of matrix metallopeptidases (MMPs) and transforming growth factor (TGF)-beta family members (Figure 4b); in contrast, cell cycle regulators (e.g., cyclins-CDKs) and stemness factors (e.g., CD24, CD44, and KIT) were upregulated in CD83-OV and negative control (NC) ovarian cancer cells (Figure 4c). The gene discussed is CD44; the disease is ovarian cancer.