We identify the activated TAK1-MEK1/2-ERK1/2 signaling, increased CDK2/cyclin B1 expression, and reduced FOXO1/p21 levels in CD83-overexpressed ovarian cancer cells, indicating that MAPK-ERK1/2-FOXO1 axis is involved in the activation of ovarian cancer cell proliferation by CD83. This evidence concerns the gene FOXO1 and ovarian cancer.