Among these, changes in the expression of C-X-C chemokine receptor type 4, C-C chemokine receptors type 5 and 9, C-C chemokine ligand 25, and C-X-C chemokine ligand 9, and of the ECM components fibronectin and laminin, have been previously related to alteration of the thymic microenvironment in malnourished subject and during infection by T. cruzi and P. berghei [9,11,13]. Here, CXCR4 is linked to infection.