Here, we show, not only that IKKβ activity is increased in KRAS-mutant lung tumourspheres (Figure 1), but also that IKKβ targeting in KRAS-mutant lung cancer cells reduces expression of stem cell factors (Figure 2), as well as KRAS-mutant lung tumoursphere formation and self-renewal (Figure 3 and Figure 4). Here, KRAS is linked to lung carcinoma.