Finally, angiogenesis contributes to metastatic dissemination by shared mediators, such as the interleukin 8 (IL-8) cytokine [25,53], and IKKβ has been shown to upregulate IL-8 to promote lung cancer angiogenesis and ovarian cancer angiogenesis and metastasis [24,54]. This evidence concerns the gene IKBKB and ovarian cancer.