Indeed, SDCBP (syndecan binding protein) has been identified as one of the dysregulated genes in grey compared to black hair follicles in human premature hair graying patients [41]; NSMAF shares a functional domain with the LYST (lysosomal trafficking regulator) gene, which is mutated in the Chediak–Higashi syndrome (CHS), a rare disorder characterized, among other features, by childhood occurrence of silvery grey colored hair [42,43,44,45,46]. Here, LYST is linked to Chediak-Higashi syndrome.