RAB27A and Chediak-Higashi syndrome: This is, for example, the case in Chediak–Higashi syndrome (mutation at the LYST gene) and its analog in several animal species; the Griscelli syndrome (dysregulation of the myosin Va, RAB27a, and SLAC2a complex); and the Hermansky–Pudlak syndrome (mutations in several different genes implicated in lysosome-related organelle biogenesis) and its analog in mice.