TP53 and neoplasm: Our gene expression results, however, indicated “cancer” genes as being differentially expressed in T2DM cases compared to controls, which was revealed through the IPA analysis (Figure 1), network connectivity (Figure 2, where TP53 stands as a central molecule in P53 Signaling Pathway), as well as a small pilot population validation of TP53 gene (Figure 4), where this tumor suppression gene is mostly downregulated.