The IPA core analysis of significant canonical pathways in T2DM subjects has also highlighted certain interconnected signaling pathways including P53 Signaling and Type 2 Diabetes Insulin Signaling in tandem with clear manifestations of Apoptosis Signaling, Molecular Mechanism of Cancer, Chronic Myeloid Leukemia, and Cell Cycle G1/S Checkpoint Regulation. The gene discussed is TP53; the disease is type 2 diabetes mellitus.