Different from feeding behaviors which are not expected to be affected by leptin levels before the fourth week of age [5], modulation of genes coding for the N-methyl-D-aspartate, GABAB or KATP channels subunits in the ARH due to postnatal overnutrition may, for example, contribute to early puberty onset or predispose individuals for other metabolic diseases. Here, LEP is linked to metabolic disease.