Indeed, MEG3 down-regulation or silencing has been associated with increased angiogenesis in human tumours (Zhang et al., 2017), Gtl2 knockout mouse models (Gordon et al., 2010) and a rat model of tissue repair after ischaemic brain injury (Liu et al., 2017).This is regulated via activation of angiogenesis related genes including Vegf, βFGF and TGF-β1. Here, FGF2 is linked to neoplasm.