VCAN and neoplasm: Macrophage cluster MF1 expressed features associated previously with tumor-infiltrating myeloid derived suppressor cells (FCN1, VCAN, S100A8, S100A9) (Zhang et al., 2019) and with THBS1 and PTX3, which are associated with resolution of inflammation, wound healing, and with inhibition of IL-1β (Bouhlel et al., 2007; Faz-López et al., 2016; Martinez and Gordon, 2014; Puig-Kröger et al., 2009; Shiraki et al., 2016; Stein et al., 2016; Zhang et al., 2019) (Figure 5B; Figure S7B).