TGFB2 and open-angle glaucoma: It is also upregulated in glaucomatous human donor eyes [14] which, along with the increased levels of TGFβ2 in the aqueous humor of POAG patients [4–8], may play a role in the pathogenesis of POAG by controlling the differentiation of TM cells into myofibroblast-like cells and altering the contractile properties of the tissue [70, 71].