The Stat2 motif was significantly correlated with the expression signature (z-value 2.707), and we observed significant activation of the Klf4_Sp3 (z-value 2.349) and Mecp-2 (z-value 2.627) transcription factor binding motifs known to be associated with AML or MDS, but significant downregulation of the Max–Mycn motif (z-value 2.016), upon transduction of d715 Csf3r lin− cells with RUNX1 mutants (Suppl. Here, RUNX1 is linked to myelodysplastic syndrome.