NPPB and obesity due to melanocortin 4 receptor deficiency: The study provided the opportunity to appreciate a more frequent use of thrombolysis and a low rate of major complications in patients with PE who have Grade 3 obesity. To our knowledge, this is the first report that examined the biomarkers’ behavior in this selected population and estimated the independent predictive value of BNP and troponin but did not include parallel imaging, which is the common practice.