PLAT and intracerebral hemorrhage: This strategy of reversing the acute platelet-rich thrombus formation, restoring baseline flow, and stabilizing the irritable endothelium may allow neuro-interventionalists to avoid intracranial stent placement and its associated risks in the acute setting [19]. Intra-arterial GPI infusion in the setting of LVO stroke syndrome patients who often have received IV tPA prior to intervention raises the question of the safety of this approach with respect to increased intracerebral hemorrhage (ICH) risk.