These criteria included the characteristic eosinophilic-mucin containing hyphae, along with a positive fungal strain or culture, in the absence of tissue invasion by fungi, in addition to other suggestive (or supportive) clinical and biological evidence of an allergy such as positive atopic history, nasal polyposis, absence of immunodeficiency, and elevation of total or specific immunoglobulin E (IgE) or a positive skin test to fungal antigens [5,13-15]. Here, IGHE is linked to immunodeficiency disease.