More recently, while several researchers debated the role of fungi in the genesis of AFS [17-21], others attempted to establish the immunologic difference between AFS and other types of chronic rhinosinusitis by highlighting the major role of allergy evidenced by significantly higher levels of allergy markers, such as total IgE, IgG anti-Alternaria-specific antibodies (UniCAP 100), and IgE antifungal antibodies in the sera of patients with AFS [22]. The gene discussed is IGHE; the disease is allergic disease.