Allegretti et al. demonstrated that EWS-FLI1 Type I and Type II rearrangements could be identified, regardless of patient-specific EWS-FLI1 DNA breakpoints in circulating tumor RNAs (ctRNAs) in 4 patients (1 metastatic and 3 localized) ranging in ages from 8–45 years utilizing 1.8 mLs of plasma. The gene discussed is EWSR1; the disease is neoplasm.